The hormone factory skin never sleeps or Methusalem drugs and other ancient friends, revisited!

The hormone factory skin never sleeps or Methusalem drugs and other ancient friends, revisited!

the “antidiabetic” drug metformin could be useful as an addon therapy to methotrexate for the treatment of psoriasis and, perhaps, for rheumatoid arthritis as well. Biochemical data suggest that both drugs may share a common cellular target, the AMP-activated protein kinase (AMPK). This enzyme is a master regulator of metabolism and controls a number of downstream targets, e.g., important for c...

Environmental science in the city that never sleeps.

Background: The phase of a circadian rhythm reflects where the peak and the trough occur, for example, the peak and trough of performance within the 24 h. Light exposure can shift this phase. More extensive knowledge of the human circadian phase response to light is needed to guide light treatment for shiftworkers, air travelers, and people with circadian rhythm phase disorders. This study test...

Humans and Other Animals—Future Friends or Foe?

Since the opening editorial, Animals has got off to an excellent start. Thirty articles were published in 2011, which comprise 446 pages of volume 1, and already 25 articles have been published this year in 360 pages of volume 2. Meanwhile the impact of other MDPI journals continues to grow; mean impact factor of the ten journals that have been in existence long enough to be assessed was 1.9, a...

Microbial Skin Inhabitants: Friends Forever

To gain insight into the stability of the microbial communities that inhabit our skin, Oh et al., in a tour-de-force effort, map the human skin metagenomes over time. Remarkably, their data indicate that the individual, not the environment, primarily drives the composition of skin microbial communities.

The other lung--revisited.